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Tumor Markers In Oral Cancer: A Review

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Molecular biology and oncology research studies on oral cancer biomarkers focus on identifying key biological molecules or markers that could be linked to cancer development, risk assessment, screening, recurrence prediction, indicating prognosis, indicating invasion/metastasis and monitoring therapeutic responses of cancer.

Tumor Markers

The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. A comprehensive review of the current

Abstract The purpose of this review is to give a brief background to enable the judicious use of widely performed serum cancer markers. The markers could be product of cancerous cell or as response to cancer. They are usually proteins, which are mainly found in blood or urine. These markers may be employed to predict primary or secondary tumor Abstract Brief Background The paper presented deals with various tumour markers which are implicated in oral cancer and their increasing importance as a diagnostic modality in oral cancer detection.

Tumor markers in oral cancer: A review

Tumor markers in oral cancer: A review Jagadish Prasad Rajguru1, Mouneshkumar C D2, Indu Cherangapadath Radhakrishnan3, Bhupender Singh Negi4, Deepthi Maya5, Sahar Hajibabaei6, Vivek Rana7 Tumor markers are substances that are produced either by the tumor itself or by the body in response to the presence of cancer or certain benign conditions that can aid in the diagnosis of cancer. These markers may be employed to predict primary or secondary tumor risk. Sometimes, non-cancerous conditions can also cause elevation of some tumor markers to be higher than Abstract Background: Oral cancer is often preceded by Potentially Malignant Disorders (PMDs) and important role of biochemical markers for early diagnosis has been well documented; however, there is limited evidence of Serum lactate dehydrogenase (SLDH) as an effective biochemical marker in diagnosis of PMDs. The present meta-analysis was conducted to

Prospective use of these markers in the clinical setting will enable early detection, prediction of response to treatment, improvement in treatment selection, and early detection of tumor recurrence for disease monitoring. However, most of Most oral cancers are oral squamous cell carcinoma using saliva for early oral cancer detection in the search for new clinical markers is a promising approach because of its noninvasive sampling

  • Journal of Cancer Research and Therapeutics
  • Exploring Salivary Biomarkers for Tumor Diagnosis: A Narrative Review
  • Prognostic relevance of molecular markers of oral cancer–a review
  • Current Insights into Oral Cancer Diagnostics

Abstract Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and accounts for >90% of all oral cancers. Despite advances in diagnostic procedures and therapeutic interventions, overall survival has not improved significantly in recent decades, primarily due to late diagnosis, locoregional recurrence and treatment resistance. Identifying

The pathogenesis of oral cancer is a complex and multifactorial process that requires a deep understanding of the underlying mechanisms involved in the development and progress of malignancy. The ever-improving comprehension of the diverse molecular characteristics of cancer, the genetic and epigenetic alterations of tumor cells, and the complex Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and accounts for >90% of all oral cancers. Despite advances in diagnostic procedures and therapeutic interventions, overall survival has not improved significantly in recent decades, primarily due to late diagnosis, locoregional recurrence and treatment resistance. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers.

(PDF) Estimation and comparative study of serum total sialic acid ...

This review provides a comprehensive elucidation of salivary biomarkers and their function in non-invasive oral cancer diagnosis, demonstrating their potential to enhance patient outcomes and reduce the impact of this devastating disease. Abstract Background: Oral cancer is often preceded by Potentially Malignant Disorders (PMDs) and important role of biochemical markers for early diagnosis has been well documented; however, there is limited evidence of Serum lactate dehydrogenase (SLDH) as an effective biochemical marker in diagnosis of PMDs. The present meta-analysis was conducted The document discusses oral cancer, detailing its epidemiology, classification by the WHO, etiology, risk factors, and management. It highlights that the primary histological type is squamous cell carcinoma, with significant risk from tobacco, alcohol, and viral infections, especially HPV. The intricate process of carcinogenesis is elaborated, addressing genetic, epigenetic, and

Abstract Background Head and neck squamous cell cancer (HNSCC) is the most common cancer associated with chewing tobacco, in the world. As this is divided in to sites and subsites, it does not make it to top 10 cancers. The most common subsite is the oral cancer. At the time of diagnosis, more than 50% of patients with oral squamous cell cancers (OSCC) had advanced

tion of patients who may benefit from a particular treatment modality or at risk for poor prognosis. Biomarkers are protein molecules, gene expression, DNA variants, or metabolites that are derived from tumors, adjacent normal tissue or bodily fluids, which can be acquired before treatment and during follow-up, thus extending their use to the evaluation of cancer progression and Background Oral squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, contributing significantly to cancer-related mortality worldwide. Circulating tumor DNA could be a promising biomarker for the early diagnosis and prognosis of oral cancer. Objective The aim of this systematic review was to consolidate the existing

We identified recurrent themes, patterns, and contradictions by a thematic analysis. We also assessed state-of-the-art salivary biomarkers for tumor diagnosis and prognosis. One major finding is the identification of biomolecules in saliva linked to several cancer forms, including pancreatic, oral, breast, lung, and stomach cancers. The salivary genomic markers Tumor-specific genomic markers consisting of DNA and RNA markers which are identified in the saliva for the detection of oral cancer considering that the initiation and progression of malignant tumors is driven by the accumulation of specific genetic alterations. DNA shows tumor-specific characteristics such as somatic mutations in tumor This document reviews tumor markers that can aid in the diagnosis and assessment of oral cancer. It discusses how tumor markers are substances

The prevalent and aggressive kind of oral cancer known as oral squamous cell carcinoma (OSCC) varies greatly in how well people respond to treatment. By directing individualised treatment approaches, the use of biomarkers in treatment stratification has grown in significance in terms of improving patient outcomes. The aim of this review is to outline the recent advances in oral squamous cell carcinomas biomarkers, exploring those related to clinical and histopathological features, cancer cells and components of the tumor microenvironment.

Oral squamous cell carcinoma (OSCC), one of the most common types of cancers worldwide, is diagnosed mainly through tissue biopsy. However, owing to the tumor heterogeneity and other drawbacks, such as the invasiveness of the biopsy procedure and high cost and limited usefulness of longitudinal surveillance, there has been a focus on adopting more rapid, Abstract. Tumor markers are playing an increasingly important role in cancer detection and management. These laboratory-based tests are potentially useful in screening for early malignancy, aiding cancer diagnosis, determining prognosis, surveillance following curative surgery for cancer, up front predicting drug response or resistance, and monitoring therapy in

The role of tumor markers in clinical oncology has increased tremendously over last decade, a trend that continues to grow as technology progresses and our understanding about human body and the disease processes increase. Tumour markers have wide applications in cancer care, starting from screening, choosing modality of management, assessment of To avoid heterogeneity among subsites of the oral cavity and to identify newly introduced histologic markers that can identify high‐risk early OTSCC, this systematic review aims to provide a critical summary of promising histopathologic features identified by HE staining that are currently not yet included in the daily practice of The impact of histopathological features on the prognosis of oral squamous cell carcinoma: a comprehensive review and meta-analysis

Molecular biology and oncology research studies on oral cancer biomarkers focus on identifying key biological molecules or markers that could These markers may be employed to predict primary or secondary tumor risk. Sometimes, non-cancerous conditions can also cause elevation of some tumor markers to be higher than normal. Besides, not every cancer patient may have raised level of a tumor marker. For these reasons, knowledge about cancer biomarkers is essential. Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. This article reviews the recently identified biomarkers for OSCC such as cytokeratins, p53, tumor necrosis factor alpha (TNF-α), etc., which are of great utility in early diagnosis. In addition, the biomarkers that have

The aim of the present article was to review the current knowledge on the prognostic value of tumour marker in the treatment of oral squamous cell carcinoma (OSCC). The literature of the past 5 years (1997-August 2002) was screened. One hundred and sixty-nine articles were included in this review, t New molecular markers for oral cancer detection, treatment, and prognosis have been found as a result of developments in the fields of molecular biology and salivary proteomics. The numerous salivary tumor biomarkers and how they relate to oral cancer and pre-cancer are covered in this article. New molecular markers for oral cancer detection, treatment, and prognosis have been found as a result of developments in the fields of