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Triple-Negative Breast Cancer: An Unmet Medical Need

Di: Ava

Triple negative breast cancer (TNBC) is characterised by a lack of clinically significant expression levels of oestrogen receptor, progesterone Introduction Triple-negative breast cancer (TNBC) represents a formidable challenge in the field of oncology, characterized by its aggressive behavior, limited treatment options, and poorer Abstract Triple-negative breast cancer (TNBC) is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast cancer. TNBC

Unmet Needs in Breast Cancer

There are limited treatment options for patients with advanced/metastatic, triple-negative breast cancer because commonly used treatments in other breast cancer segments (i.e., hormonal Abstract Triple-negative breast cancer (TNBC) is a very heterogeneous and aggressive breast cancer subtype with a high risk of mortality, even if diagnosed early. The

Hot issues in triple-negative breast cancer | Cancer Biology & Medicine

Triple negative breast cancer (TNBC) is an aggressive clinical phenotype characterized by lack of expression (or minimal expression) of estrogen receptor (ER) and

Learn about metastatic triple-negative breast cancer (mTNBC) and the treatment challenges associated with the disease. Abstract Triple negative breast cancer (TNBC) is an aggressive clinical phenotype characterized by lack of expression (or minimal expression) of estrogen receptor (ER) and progesterone Dr. Priyanka Sharma Question: Given the high unmet need in triple-negative breast cancer (TNBC), do clinicians consider usage of

Purpose The transition from a breast cancer patient to a survivor can be associated with significant physical, psychological, and social challenges. Development of

About Metastatic Triple-Negative Breast Cancer

Triple negative breast cancer (TNBC) is characterized by the lack of estrogen and progesterone receptor expression and lacks HER2 overexpression or gene amplification. Treatment options for triple-negative breast cancer (TNBC), which is ER negative, PR negative, and HER-negative, are more limited because of the lack of therapeutic targets. 3

Friday, Mar 8, 2019 FDA Grants Genentech’s Tecentriq in Combination With Abraxane Accelerated Approval for People With PD-L1-Positive, Metastatic Triple-Negative Breast 396P Real-world treatment and survival outcomes in previously untreated patients with metastatic triple-negative breast cancer (mTNBC) in the United States (US) Triple-negative breast cancer (TNBC) is a biologically and clinically heterogeneous disease, which has long been considered to present a major unmet need due to its aggressive

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Triple negative breast cancers (TNBC) without BRCA1/2 gene mutation or BRCAness are nowadays the breast malignancies most difficult to treat. Improvement of their

Poor Response of Metaplastic Triple-Negative Breast Cancer to Neoadjuvant Chemoimmunotherapy: An Unmet Oncological Need [abstract]. In: Proceedings of the San

Hope and Hype around Immunotherapy in Triple-Negative Breast Cancer

Endeavors for addressing the unmet medical needs of triple-negative breast cancer (TNBC) patients are allowing the medical community to understand its biological Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor Currently, along with clinical and diagnostic unmet needs, QoL among breast cancer survivors is also being highlighted as a major unmet

Understanding Triple-Negative Breast Cancer: Factors, Symptoms ...

This real-world study describes the treatment landscape evolution after targeted therapy approval and associated survival outcomes for previously untreated metastatic triple-negative breast

Abstract Triple-negative breast cancer (TNBC) (ER−/PGR−/erb-2−) constitutes an aggressive subtype in breast cancer because it is accompanied by a significant decrease in In the OptiTROP-Breast01 phase 3 trial, patients with metastatic triple-negative breast cancer who received the TROP2-targeted antibody–drug conjugate sacituzumab

Triple negative breast cancer (TNBC) is an aggressive clinical phenotype characterized by lack of expression (or minimal expression) of estrogen receptor (ER) and Abstract Triple negative breast cancer (TNBC), an aggressive variant of breast cancer, is characterized by lack of expression of the estrogen (ER) and progesterone receptors

Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer and disproportionately accounts for the majority of breast cancer related deaths. Here, we report the unusual case of a patient who was diagnosed initially with triple-negative breast cancer (TNBC) but whose cancer progressed as ER-positive diffuse skin metastases Triple-negative breast cancer (TNBC) poses significant challenges in oncology due to its aggressive nature, limited treatment options, and poorer prognosis compared to other

Triple-negative breast cancer is an aggressive disease with high unmet need. There has been a historical lack of targeted therapies, although the treatment landscape has evolved with the

Treatment of triple-negative breast carcinoma (TNBC) remains an unmet medical need with no targeted therapy available to date. Accounting for 10-30% of all human breast cancer tumors, Triple-negative breast cancer (TNBC), characterized by the absence or low expression of estrogen receptor (ER), progesterone receptor

Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Triple-negative breast cancer (TNBC) tumors are biologically aggressive breast cancer. On the molecular level, TNBC is a highly heterogeneous disease; more Abstract Purpose: This study evaluated treatment patterns and clinical outcomes among patients with metastatic triple-negative breast cancer (mTNBC) in real-world clinical settings in Japan.

Triple negative breast cancer (TNBC) is one of the most aggressive and complex types of breast cancer to treat. Because TNBC lacks the estrogen receptor, progesterone

Articles were included if “unmet medical need” was specifically used to describe a cancer indication (eg, first line, triple-negative breast cancer), or a treatment for a specific Before closing out their discussion on CDK4/6 inhibition in HR+/HER2- metastatic breast cancer, experts highlight remaining unmet needs in this setting.

Overview of BRCAm breast cancer Patients with loss-of-function mutations in BRCA1 or BRCA2 can present with a more aggressive BC phenotype, including triple-negative