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Shenlian Extract Decreases Mitochondrial Autophagy To Regulate

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This study revealed that crosstalk between macrophage and SMC forms a holistic entirety promoting atherosclerotic plaque stability. Keywords: atherosclerotic plaques stability; macrophage polarization; shenlian extract; smooth muscle cells phenotype switching; transforming growth factor-β.

Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow. Li JJ, Wang YJ, Wang CM, Li YJ, Yang Q, Cai WY, Chen Y, Zhu XX Shenlian Extract Against Myocardial Injury Induced by Ischemia Through the Regulation of NF-κB/IκB Signaling Axis

The link between mitochondrial life cycle and PGC-1α. Mitochondrial ...

Recently, mitochondria-selective autophagy termed mitophagy has emerged as a central player for maintaining mitochondrial homeostasis by elimination of damaged mitochondria, leading to the Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no‐reflow Article Feb 2023 Jing-Jing Li Ya-Jie Wang Chun-Miao Wang Protective effects of Shenlian extract on myocardial infarction of rats by regulating mitochondrial autophagy and intervening inflammasomes activation. China Academy of Chinese Medical Sciences. 2021.

Dependence of PINK1 accumulation on mitochondrial redox system

WB analysis of pig brain using 66527-1-Ig pig/rat/mouse brain tissues were subjected to SDS PAGE followed by western blot with 66527-1-Ig (MFF antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow 参莲提取物降低线粒体自噬调节微血管线粒体功能减轻冠状动脉无复流 The mitochondrial damage was evaluated using JC‑1 staining and mitochondrial reactive oxygen species detection. The activation of mitophagy was assessed using immunofluorescence and western blotting. As a result, IGF‑1 significantly restored the survival rate in macrophages, while the apoptosis was inhibited through mitochondrial pathway.

Mitochondrial dysfunction is a key mechanism of MDD: Mitochondrial dysfunction (including DNA mutations, autophagy imbalance, homeostasis, impaired biosynthesis, and energy metabolism disorders) is considered to be the central pathogenic mechanism of MDD. These dysfunctions lead to imbalances in energy metabolism and neuroinflammation, which in turn Therefore, one possible method to prevent and manage OP may be to use mitochondria as a carrier to trigger osteogenic differentiation of bone marrow mesenchymal stem cells from mitochondrial energy consumption, oxidative stress, autophagy, and osteoclast death.

MFF (mitochondrial fission factor) is a mitochondrial outer membrane protein that is involved in mitochondrial localization of Drp1 and mitochondrial fission. Multiple isoforms of MFF exist due to the alternative splicing. This antibody recognizes the endogenous MFF protein around 26-29 kDa and 35-38 kDa. Li JJ, Wang YJ, Wang CM, Li YJ, Yang Q, Cai WY, et al. Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow. Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no‐reflow Article Feb 2023 Jing‐Jing Li Ya‐Jie Wang

Li JJ, Wang YJ, Wang CM, Li YJ, Yang Q, Cai WY, et al. Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow. Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow 参莲提取物降低线粒体自噬调节微血管线粒体功能减轻冠状动脉无复流 Ethnopharmacological relevance: Shenlian extract (SL), extracted from Salvia miltiorrhiza Bunge and Andrographis paniculata (Burm. f.) Nees, has been proved to be effective in the prevention and treatment of atherosclerosis. Recently, we have partially elucidated the mechanisms involved in the therapeutic effects of SL on myocardial ischemia (MI).

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging PINK1 and parkin: emerging themes in mitochondrial homeostasis Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome 清晨好，您是今天最早来到科研通的研友！由于当前在线用户较少，发布求助请尽量完整的填写文献信息，科研通机器人24小时在线，伴您科研之路漫漫前行！ 已完结 文献求助详情

G蛋白通路抑制因子2在机械通气肺损伤中的调控作用及机制

ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques Mechanisms of mitochondria and autophagy crosstalk ROS, mitochondria and the regulation of autophagy Autophagy and the degradation of mitochondria ER-mitochondria contacts as sites of mitophagosome formation Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative To Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow. Phytother Res. 2023;37:1864–1882. doi: 10.1002/ptr.7703.

Induction of autophagy decreases mitochondrial oxidative stress and ...

Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow Jing-Jing Li, Ya-Jie Wang, Chun-Miao Wang, Yu-Jie Li, Qing Yang, Wei-Yan Cai, Ying Chen, Xiao-Xin Zhu Research has shown that hypoxia damages mitochondria through HIF1α and regulates mitochondrial autophagy by controlling BNIP3 translocation to mitochondria [194]. Air pollution is a growing public health burden associated with several negative health effects, especially cardiovascular disease. Shenlian extract (SL), a traditional Chinese medicine, has the effects of clearing heat-toxin and promoting blood circulation for removing blood stasis, and it

This study was designed to investigate the contribution of SL extract in repressing excessive mitochondrial autophagy to protect the mitochondrial function and prevent coronary artery no‐reflow.

Shenlian formula has renal protective effect on diabetic kidney disease (DKD) and alleviate renal interstitial fibrosis (RIF). Shenlian formula could mitigate inflammation-induced renal damage and interstitial fibrosis by modulating the autophagy pathway to inhibit cell pyroptosis, offering novel insights for the research on the mechanisms of Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no‐reflow Article Feb 2023 Jing-Jing Li Ya-Jie Wang Chun-Miao Wang Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow 参莲提取物降低线粒体自噬调节微血管线粒体功能减轻冠状动脉无复流

Our previous studies showed that Shenlian extract (SL) could prevent the formation of atherosclerosis and enhance the stability of atherosclerotic plaques. To further investigate the protective effects of SL on myocardial ischemic injury and its possible mechanisms, anesthetized dogs, ex vivo rat hearts, and H9c2 cardiomyocytes were used as

Context Shenlian extract (SL) is a combination of Salvia miltiorrhiza Bge. (Labiatae) and Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae) extracts, which promote blood circulation and clear endogenous heat toxins. Myocardial ischaemia-reperfusion injury (MI/RI) is aggravated myocardial tissue damage induced by reperfusion therapy after Article „Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow“ Detailed information of the J-GLOBAL is an information service managed by the Japan Science and Technology Agency (hereinafter referred to as „JST“). It provides free access to secondary information on researchers, articles, patents, Li JJ , Wang YJ , Wang CM ,et al. Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in m icrovascular to alleviate coronary artery no-reflow [J].

Accumulation of PINK1 on the outer mitochondrial membrane (OMM) is necessary for PINK‐mediated mitophagy. The proton ionophores, like carbonyl cyanide m‐chlorophenylhydrazone (CCCP) and

Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no‐reflow Jing-Jing LiYa-jie Wang +5 authors Xiao-xin Zhu Medicine, Environmental Science Phytotherapy research : PTR 2023 TLDR Mitochondrial autophagy is coordinated with mitochondrial biogenesis, ensuring a healthy mitochondrial network through the recycling of mitochondrial components (Wang et al., 2024).