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Per3 Variable Number Tandem Repeat Polymorphism

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The coding region of Per3 gene contains a variable-number tandem-repeat (VNTR) polymorphism which has been associated with diurnal preference, sleep structure and sleep homeostasis in healthy subjects. A link between diurnal preference and a variable number tandem-repeat (VNTR) polymorphism in the PERIOD3 gene (PER3) has been demonstrated: the longer PER3 5 and shorter PER3 4 alleles with preferences for mornings and evenings, respectively. As many

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(2019) Carvalho et al. Scientific Reports. We evaluated the circadian pattern of variation of the descending pain modulatory system (DPMS) using a conditioned pain modulation (CPM) paradigm according to the variable-number tandem-repeat (VNTR) of the clock gene PER3 polymorphism. We assessed the

PER3 variable number tandem repeat polymorphism

Possible Association of PER2/PER3 Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics

A variable-number tandem repeat (VNTR) polymorphism (rs57875989) in the PER3 gene (located on chromosome 1p36.23), consisting of two alleles of four or five tandem 54 bp repeats (coding for a region of 18 amino acids in exon 18), has been evaluated as a potential genetic factor for chronotypes and other circadian phenotypes [2, 5].

PER3 variable number tandem repeat (VNTR) polymorphism modulates the circadian variation of the descending pain modulatory system in healthy subjects. Findings suggest that the polymorphism of PER35/5 is associated with a decrease in the inhibitory function of the DPMS over the course of the day, regardless of the PER3 VNTR polymorphism. We evaluated the circadian pattern of variation of the descending pain modulatory system (DPMS) using a conditioned pain modulation (CPM) paradigm according to the variable

The PER3 gene is one of the clock genes, which function in the core mammalian molecular circadian system. A variable number of tandem repeats (VNTR) locus in the 18th exon of this gene has been As a result, it was demonstrated that a variable number of tandem repeats (VNTR) polymorphism in the clock gene PER3 is associated with morningness-eveningness tendencies. 6, 7, 8 Polymorphisms in the PER3 gene have been associated with several human disease phenotypes, including sleep disorders and cancer. In particular, the long allele of a variable number of tandem

A link between diurnal preference and a variable number tandem-repeat (VNTR) polymorphism in the PERIOD3 gene (PER3) has been demonstrated: the longer PER3(5) and shorter PER3(4) alleles with preferences for mornings and evenings, respectively. As many competitive events in South Africa for individual athletes are scheduled for the early mornings,

8.3: Variable Number Tandem Repeats

Period homologue 3 (PER3) is a component of the mammalian circa-dian system, although its precise role is unknown. A biallelic variable number tandem repeat

Short tandem repeats (STRs) are genomic regions consisting of repeated sequences of 1–6 bp in succession. Single-nucleotide polymorphism (SNP)-based g We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness–eveningness Background Clock genes regulate circadian rhythm and are involved in various physiological processes, including digestion. We therefore investigated the association between the CLOCK 3111T/C single nucleotide polymorphism and the Period3 (PER3) variable-number tandem-repeat polymorphism (either 4 or 5 repeats 54 nt in length) with morning gastric

A variable-number tandem repeat (VNTR) in the human clock gene PERIOD3 (PER3) has been suggested to correlate with a morning (lark) versus evening (owl) chronotype as well as with the circadian rhythm sleep disorder ?delayed sleep phase disorder? (DSPD).

Variable Number Tandem Repeats

Background: The variable number tandem repeat (VNTR) polymorphism 5-repeat allele of the circadian gene PERIOD3 (PER3 (5/5)) has been associated with cognitive decline at a specific circadian The PER3 gene is one of the clock genes, which function in the core mammalian molecular circadian system. A variable number of tandem repeats (VNTR) locus in the 18th exon of this gene has been Summary Variable number tandem repeat (VNTR) is a pervasive and highly mutable genetic feature that varies in both length and repeat sequence. Despite the well-studied copy-number variants, the functional impacts of repeat motif polymorphisms remain unknown.

生物节律基因period3的研究进展

Part of this variation may be due to genetic differences at the variable number tandem repeat (VNTR) polymorphism of the PERIOD3 (PER3) gene as this polymorphism has been associated with ABSTRACT In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss.

Abstract A link between diurnal preference and a variable number tandem-repeat (VNTR) polymorphism in the PERIOD3 gene (PER3) has been demonstrated: the longer PER35 and shorter PER34 alleles with preferences for mornings and evenings, respectively.

Period homologue 3 (PER3) is a component of the mammalian circa-dian system, although its precise role is unknown. A biallelic variable number tandem repeat (VNTR) polymorphism exists in human The present case–control research was carried out to estimate the possible association between PERIOD2/PERIOD3 (PER2/PER3) gene variable number tandem repeat polymorphism (VNTR) variants and PC in the Turkish population. Materials and Methods: A total of 198 subjects (78 patients with PC and 120 healthy controls) were enrolled in this work. Tandem Repeats A type of polymorphism occurs due to these repeats expanding and contracting in non-coding regions. These regions are called variable number tandem repeats (VNTRs)or sometimes short tandem repeats (STRs). Any region or location on a chromosome is referred to as locus (loci for plural).

An association has been determined between variable number tandem-repeat (VNTR) polymorphisms in the PERIOD3 gene (PER3, rs57875989) and chronotype. An association has been found in which the A well-studied PER3 polymorphism in exon 18, rs57875989, encodes a variable number tandem repeat region (VNTR) containing a motif of 54 base pairs or 18 amino acids. This motif region encodes multiple CKI phosphorylation sites and the motif repeats either four or five times within the variant alleles.

PERIOD3, circadian phenotypes, and sleep homeostasis

We quantified the contribution of a variable-number tandem-repeat polymorphism in the coding region of the circadian clock gene PERIOD3 (PER3) [9, 10] to sleep-wake regulation in a prospective study, in which 24 healthy participants were selected only on the basis of their PER3 genotype. PER3 A length polymorphism in PER3 was reported by Archer et al. (2003) to be linked to delayed sleep phase disorder and extreme diurnal preference. This length polymorphism is due to a variable-number tandem repeat (VNTR, 4 or 5 repeats) in PER3. The shorter 4 allele was found to have a strong association with delayed sleep phase disorder.

We evaluated the circadian pattern of variation of the descending pain modulatory system (DPMS) using a conditioned pain modulation (CPM) paradigm according to the variable-number tandem-repeat (VNTR) of the clock gene PER3 polymorphism. We assessed Here we show that two PER3 mutations, a variable number tandem repeat (VNTR) allele and a single-nucleotide polymorphism (SNP), are associated with diurnal preference and higher Trait-Anxiety

PER3 variable number tandem repeat (VNTR) polymorphism modulates the circadian variation of the descending pain modulatory system in healthy subjects Fabiana Carvalho1,2, Mario Pedrazzoli3, Assunta Gasparin1,2, Franciele dos Santos2,4, Maxciel Zortea1,2, Andressa Souza2,5, Iraci da Silva Lucena Torres6, Felipe Fregni7 & Wolnei Caumo 1,2,8,9 Abstract In humans, a primate-specific variable-number tandem-repeat (VNTR) polymorphism (4 or 5 repeats 54 nt in length) in the circadian gene PER3 is associated with differences in sleep timing and homeostatic responses to sleep loss.