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Novel Carrier-Free Nanodrug Enhances Photodynamic Effects By

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请遵守相关知识产权规定，勿将文件分享给他人，仅可用于个人研究学习 To compensate, carrier-free nanodrugs (NPs), made up of pharmacological active molecules, have been studied. It is a challenge for designing new carrier-free NPs with chemotherapy-PDT synergistic anti-tumor effects, which could also deplete GSH to elevate ROS levels and enhanced the PDT treatment.

Carrier-free Nanodrug for the Chemical-Photodynamic Synergistic ...

Proteolysis-targeting chimeras (PROTACs) selectively degrade target proteins by recruiting intracellular E3 ubiquitin ligases, overcoming the limitations of traditional small-molecule inhibitors that merely block protein function. This approach has garnered significant interest in precision cancer therapy. However, the clinical translation of PROTACs is hindered by their There are tremendous challenges from both tumor and its therapeutic formulations affecting the effective treatment of tumor, including tumor recurrence, and complex multistep preparations of formulation. To address these issues, herein a simple and green approach based on the self-assembly of therapeutic agents including a photosensitizer (chlorine e6, Ce6) and a

Of note, carrier-free nanomedicine attracts great attention for clinical translation with synergistic antitumor effect, which is characterized by high drug loading, simplified synthetic method and good biocompatibility.

Advance Progress in Assembly Mechanisms of Carrier-Free

Cited 0 Views 0 Bibtex Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer Luoyijun Xie, Li Wang, Ling Li, Chutong Liu, Lihao Guo, Yingying Liao, Shuyi Zhou, Weiwei Wu, Yanhong Duo, Leilei Shi, Miaomiao Yuan Photodynamic therapy (PDT) is a promising approach to treating glioblastoma and other cancers. Here, a new pure-drug nanoparticle of verteporfin (NanoVP) is introduced to significantly improve photosensitizer delivery, enhance PDT efficacy, and increase the permeability of the blood-brain barrier. This new photosensitizer nanoformulation opens up Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer.

Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer Finally, a future perspective is introduced to highlight the existing challenges and possible solutions toward clinical application of currently developed carrier-free nanodrugs, which may be instructive to the design of effective carrier-free regimens in the future.

With more synthetic approaches for the preparation of carrier-free nanodrugs than ever, we expect a range of new carrier-free formulations to be developed and employed in cancer therapy in future. Specifically, we constructed CASN, a carrier-free photodynamic bioregulator, through the self-assembly of the photosensitizer Chlorin e6 and monocarboxylate transporter 1 (MCT1) inhibitor AZD3965. CASN exhibited a uniform structure, good stability, and Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer. Luoyijun Xie,Li Wang,Ling Li,Chutong Liu,Lihao Guo,Yingying Liao,Shuyi Zhou,Weiwei Wu,Yanhong Duo,Leilei Shi,Miaomiao Yuan

Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer ACS Applied Materials & Interfaces (IF 8.2) Pub Date: 2024-01-23 , DOI: 10.1021/acsami.3c17977 The theophylline derivative d17 is a candidate drug for nonsmall cell lung cancer (NSCLC) treatment previously developed by our group.

Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer Luoyijun Xie, Li Wang, Ling Li, Chutong Liu, Lihao Guo, Yingying Liao, Shuyi Zhou, Weiwei Wu, Yanhong Duo, Leilei Shi, Miaomiao Yuan Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer

Carrier-free nanodrugs for safe and effective cancer treatment

Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. Ursolic acid (UA) is a food-plant-derived natural product which has good anticancer activities and low toxicity. However, the poor water solubility of UA limits its application in clinic. To address this issue, we developed a carrier-free nanodrug by self-assembly of UA. Here, we showed that UA nanoparticles (NPs) have a near-spherical shape with a diameter of ∼150 nm.

A Size‐Reducible Nanodrug with an Aggregation‐Enhanced Photodynamic ...

In this study, a novel HA functionalized carrier-free nanoparticles with ultrafine nanostructure are successfully prepared by microfluidic precise co-assembly. A possible two-step co-assembly mechanism is proposed to ensure precise functional integration of HA@H-T. HA is used as a structure-directing agent to manipulate the growth Such carrier-free nanodrug systems could improve drug efficacy, avoid possible side effects related to carrier materials, and facilitate large-scale production with simple formulation to provide long-term benefits.

Till now, carrier-free nanoparticles for tumor theranostics, phototherapy, chemotherapy, diagnose and synergistic therapy, have made outstanding progress. In this review, we make an integrated and exhaustive overview of lately reports on carrier-free nanodrug delivery systems formed by several active agents. Carrier-free nanomedicines have garnered significant interest due to their distinct composition, lacking additional carrier materials, which can significantly reduce organismal immune responses and toxicity. This review focuses on the latest design strategies and biomedical applications of carrier-free nanomedicine, emphasizing their unique characteristics In this study, a carrier-free nanodrug formulation composed of Torin 1 as mTORC1/C2 dual inhibitor and Verteporfin as a photosensitizer and Yes-associated protein inhibitor is developed. These two drug molecules can self-assemble into stable nanoparticles through π-π stacking and hydrophobic interactions with good long-term stability.

Taken together, these findings underscore the significant potential of this multifunctional carrier-free nanodrugs for the targeted delivery of GA, thereby laying a foundation for future endeavors aimed at developing novel formulations of hydrophobic antitumor drugs.

However, drug nanocarriers still have some concerns regarding potential issues such as unclear metabolism, carrier-induced toxicity, inflammation of kidney and other organs, and other uncertainties [13]. Therefore, it is very necessary to develop a novel nanodrug delivery system with low side effects. Till now, carrier-free nanoparticles for tumor theranostics, phototherapy, chemotherapy, diagnose and synergistic therapy, have made outstanding progress. In this review, we make an integrated and exhaustive overview of lately reports on carrier-free nanodrug delivery systems formed by several active agents.

Paclitaxel (Ptx), a type of microtubule depolymerization inhibitor, is one of the main components in gastric cancer chemotherapy. Some studies have demonstrated that tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has potential antitumor effects in several cancers. Aside from the direct anticancer effect, Tet is proved to synergistically enhance the antitumor effect of

Supporting Information A Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking Autophagy Pathway and Synergistically Trigger Immunogenic Cell Death for Efficient Treatment of Breast Cancer

Nanocarriers have been widely studied and applied in the field of cancer treatment. However, conventional nanocarriers still suffer from complicated preparation processes, low drug loading, and potential toxicity of carriers themselves. To tackle the hindrance, carrier-free nanodrugs with biological activity have received increasing attention in cancer 标题 Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer 新型无载体纳米药物通过阻断自噬途径增强光动力效应，协同触发免疫原细胞死亡，有效治疗乳腺癌 相关领域

Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration and accumulation of oxidative substance, would severely impede neurological functional recovery and lead to permanent and profound neurologic deficits and even disability. Methylprednisolone (MP) is the most commonly used clinical anti-inflammatory drug for SCI Novel Carrier-Free Nanodrug Enhances Photodynamic Effects by Blocking the Autophagy Pathway and Synergistically Triggers Immunogenic Cell Death for the Efficient Treatment of Breast Cancer