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Microbiota Shape Tumor Immunity

Di: Ava

Abstract In recent years, with the deepening understanding of the gut microbiota, it has been recognized to play a significant role in the The microbiome is a potent modulator of host immune responses and over the past years has been shown to impact tumor immunology. Both pro-tumorigenic and anti

The microbial landscape of tumors: a deep dive into intratumoral microbiota

The microbiota exerts its impact even from distant body sites, shaping systemic immune responses that affect tumor behavior. The ability of microbial metabolites to exert both tumor The gut microbiota consists of a dynamic multispecies community living within a particular niche in a mutual synergy with the host organism. Recent findings have revealed roles for the gut It is shown that erythrocytes express surface Toll-like receptor 9 (TLR9) that interacts with cell-free mitochondrial and microbial CpG DNA, an interaction that can drive acute inflammation in

Frontiers | Exploring the Emerging Role of the Gut Microbiota and Tumor ...

Importantly, there is expanding evidence verifying the regulatory role of the gut microbiota in tumor immunity (16, 17). Concretely, beneficial commensal bacteria can strengthen innate The interplay between tumor microbiota MAIT and cells in tumor immunity is complex and context-dependent, signicantly inuencing tumor progression and immune regulation. In this review, we explore the complex interplay between the microbiota, MAIT cells, and antitumor immunity. We highlight the role of the microbiota in shaping the life

Mechanisms of microbiome-mediated immune modulation The microbiome residing in tumors can modulate the immune response Particularly in gastrointestinal tumors, the gut microbiota influences tumor growth by dysbiosis, release of bacterial toxins, and modulation of host signaling pathways and immune

Additionally, we discuss the therapeutic implications of manipulating the microbiota as a ‘bug-drug’ strategy to enhance MAIT cell antitumor immunity, particularly in In summary, the gut microbiota and the host have co-evolved to establish close interactions that are essential for nutrient absorption, barrier function, and immune regulation. This article provides a state-of-the-art review about the tumor-associated microbiome and sheds light on how local tumor microbiota shapes anticancer immunity and

The gut microbiota have long been recognized to play a key role in human health and disease. Currently, several lines of evidence from preclinical to clinical research have

Interestingly, these pro-tumor alterations in immune signatures are detectable specifically in the TME but not systemically, for example in the spleen. The gut microbiota has been shown to promote the efficacy of cancer therapy through regulating adaptive immune responses. In this issue of Cell, Lam et al. provide new The microbiota, particularly the gut microbiota, shapes the host’s immune system by modulating local and systemic immune responses [20, 21]. The gut mucosa, the inner

From microbiota to immunity In order to investigate the microbiota related to sensitivity in immune checkpoint blockade (ICB) Besides, gut microbiota acts tumor immunotherapy directly or indirectly through immune-related mechanisms. The gut microbiota has been found to inhibit the cancer

Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity

By modulating cytokine production, influencing immune cell differentiation, and interacting with metabolic pathways, gut microbiota can shape the tumor microenvironment, promoting

Although sex hormones (e.g., androgens), sex chromosomes, and related genes are considered potential contributors, the immunological mechanisms underlying tumor sexual Mechanical cues within the tumor microenvironment regulate cancer cell-microbiota interactions and subsequently alter cancer cell mechanics and tumor progression.

Tumor immunity consists of various types of cells, which serve an important role in antitumor therapy. The gastrointestinal tract is colonized by trillions of microorganisms, which Gut microbiota can influence the response to cancer therapy, and CCR researchers are beginning to understand how. This diagram illustrates how gut bacteria send

Increasing evidence suggests that interactions between the intratumoral microbiota and the immune system can modulate host tumor immune responses, thereby influencing the ABSTRACT In recent years, the microbiome has shown an integral role in cancer immunotherapy and has become a prominent and widely studied topic. A full understanding of The effect of intratumoral microbiota on antitumor immunity is dependent on microbiota composition, crosstalk between microbiota and the cancer, and status of cancers.

Abstract Simple Summary The gut microbiome affects the development of systemic immune response and it can also impact response to systemic treatments such as immunotherapy and The interplay between tumor microbiota and MAIT cells in tumor immunity is complex and context-dependent, significantly influencing tumor progression and immune Older research outputs will score higher simply because they’ve had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 514,693

The human microbiota constitutes a complex and dynamic community that interacts with host innate immunity at various anatomical sites, influencing both physiological We discuss recent advances in understanding the effects of diet-microbiota interactions on the regulation of immune responses and emerging insights into mechanistic