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Measurement Of Airway Hyperresponsiveness In Mice

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In this study, we established a murine model of ACO by OVA challenge in SP‐D‐deficient mice that spontaneously developed pulmonary emphysema and investigated airway Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway hyperresponsiveness in mice. Shalaby KH, Gold LG, Schuessler TF, Martin JG, Robichaud A. Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness.

Experimental design a, Model of allergen-induced airway... | Download ...

However, it has been shown that relief of airway inflammation and airway hyperresponsiveness could be successfully achieved using a specific TRPA1 inhibitor (HC The objective of the study is to investigate the protective effect of Ginkgolide B on house dust mite (HDM)-sensitized asthmatic mice and its potential mechanism involving the

Measurement of EF 50 to inhaled bronchoconstrictors by head-out body plethysmography is a valid measure of airway hyperresponsiveness in mice and correlated closely with simultaneous Abstract Rationale: Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled methacholine, which computer simulations of lung impedance suggest is due to Shalaby KH, Gold LG, Schuessler TF, Martin JG, Robichaud A. Combined forced oscillation and forced expiration measurements in mice for the assessment of airway

Methods in Assessment of Airway Reactivity in Mice

We assessed airway hyperresponsiveness to methacholine noninvasively on days 14, 15, 18, or 22; we studied the same mice 24 h later while they were anesthetized for invasive Measurement of AR to inhaled methacholine by barometric whole-body plethysmography is a valid indicator of airway hyperresponsiveness after allergic sensitization in mice, and it is Airway hyperresponsiveness has also been re- ported in hMPV-infected mice, but for a much shorter period of time—that is, for only 3–4 days after challenge with a lower inoculum [24].

In experimental animals, airway responsiveness is commonly assessed using measurements of lung mechanics acquired during tidal breathing or using forced oscillation

Pathologic changes, including inflammation and remodeling, occur in the asthmatic airway. However, their relative contribution to the components of airway hyperresponsiveness

  • Antagonizing cholecystokinin A receptor in the lung attenuates
  • Asthma & Airway Hyperresponsiveness
  • flexiVent System Techniques & Measurements

This chapter provides an outline of the procedures necessary to measure airway hyperresponsiveness to inhaled methacholine in mouse models of allergic lung disease. We The measurement of EF50 together with basic respiratory parameters is particularly appropriate for simple and repeatable screening of pulmonary function in large numbers of

We conclude that measurement of EF (50) to inhaled bronchoconstrictors by head-out body plethysmography is a valid measure of airway hyperresponsiveness in mice. Abstract Airway hyperresponsiveness (AHR) has long been considered a cardinal feature of asthma. The development of the measurement of AHR forty years ago initiated many important

The mice were subsequently exposed to aerosolized ovalbumin or vehicle, respectively, on days 14–22. We assessed airway hyperresponsiveness to methacholine noninvasively on days 14, No report has as yet directly investigated the ability and utility of repetitive invasive and noninvasive lung function methods to assess allergen-specific EAR and

Background Airway hyperresponsiveness (AHR) is a functional abnormality characteristic of bronchial asthma [1]. AHR in asthma is defined as an exaggerated response of Measurement of AR to inhaled methacholine by barometric whole-body plethysmography is a valid indicator of airway hyperresponsiveness after allergic sensitization in mice, and it is To the Editor: Mucous obstruction may be an important component of airway hyperresponsiveness (AHR), an idea that has received support by Dr. Lundblad and

Hamelmann E, Schwarze J, Takeda K et al (1997) Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med

Objectives: To examine the role of estrogen receptors in modulating lung function and airway responsiveness using estrogen receptor–deficient mice. Methods: Lung function Abstract A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c mice. With head-out body plethysmography and the decrease in Early airway responsiveness (EAR). Noninvasive vs. invasive assessment of airway hyperresponsiveness to inhaled allergen. Groups were separated into invasively and

Asthma & Airway Hyperresponsiveness Asthma is a complex disease, whose principal characteristics include reversible airflow obstruction, airway

Mouse models have become an indispensable tool in translational research of human airway disease and have provided much of our Rationale: Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled methacholine, which computer simulations of lung impedance suggest is due to enhanced lung

Airway hyperresponsiveness, airway inflammation, and re-versible airway obstruction are physiological hallmarks of asthma. These responses are increasingly being studied in murine Methods Animal models of chronic asthma were established using IL-37a and IL-37b transgenic mice with C57BL/6J background and wild-type (WT) mice sensitized and Measurement of airway hyperresponsiveness in acetylcholine (ACH)-challenged mice. The Penh values of the four groups were measured. The results are expressed as the mean ± SD.

Allergen-sensitized and -challenged mice developed airway hyperresponsiveness as measured by EF50to aerosolized MCh compared with that in control animals. This response was associated Increases in airway resistance have also been utilized to measure direct activation of lung-resident mast cells in a model of passive anaphylaxis [12]. Here we provide an

Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness. – Shalaby KH, Gold LG, We conclude that measurement of EF (50) to inhaled bronchoconstrictors by head-out body plethysmography is a valid measure of airway hyperresponsiveness in mice. Persistent asthma is an allergic disease characterised by airway inflammation ( [1 – 5]) and hyperresponsiveness to external stimuli ( [1]). Mouse models of allergic airway

Abstract Mouse models have become an indispensable tool in translational research of human airway disease and have provided much of our understanding of the pathogenesis of airway