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Kidney Endothelial Cell Heterogeneity, Angiocrine Activity And

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Human Fetal Endothelial Cells Show Organ-Specific Heterogeneity Ex Vivo (A) (A) Representative immunofluorescence images of frozen tissue sections from fetal human kidney, lung, liver, and heart stained with antibodies against CD144 (i) and vWF (ii) with merged (iii) and zoomed (iv) views, and (v) CD31 and vWF. Scale bar: 50 μm (i–iii, v) and 25 μm (iv). (B–D) Source: Vascular Pharmacology – December 20, 2022Category: Drugs & Pharmacology Authors: Domenico Ribatti Giovanni Ligresti Roberto F NicosiaSource Type: research More News: Drugs & Pharmacology | Urology & Nephrology Abstract ‘Angiodiversity’ refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within the microvascular beds of different organs. Organotypically differentiated EC ranging from continuous, barrier-forming endothelium to discontinuous, fenestrated endothelium perform organ-specific functions such

Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches that deploy sets of growth factors We used single-cell RNA sequencing data generated by the Tabula Muris consortium to uncover transcriptional networks that maintain tissue-specific EC identity and to identify novel angiocrine and functional relationships between tissue-specific ECs.

Frontiers | Cellular heterogeneity and stem cells of vascular ...

Micro- and macrovascular endothelial cells (ECs) are characterized by structural and functional heterogeneity, which is also reflected in their secretory activity. The root of this heterogeneity and related regulatory mechanisms are still poorly understood. Endothelial cells are of great importance in many types of diseases including the coronary artery diseases in heart and stroke in brain. In this review, we explore the heterogeneity among endothelial cells from an organism-wide, organ-specific, and

Kidney Microvascular Endothelium

The vascular endothelium is highly heterogeneous, with phenotypically and functionally distinct endothelial cell (EC) subtypes, partially driven by distinct metabolic programs. While this heterogeneity is important to maintain the multiple functions of the endothelium during tissue repair, it also contributes to challenges to therapeutically modulate ECs in pathological Melero-Martin and colleagues developed a rapid method to generate vascular organoids from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1. This strategy enabled controlled co-differentiation of vascular cells and supported in vivo engraftment, offering a versatile platform for vascular biology, tissue engineering, and Abstract Endothelial cells secrete growth factors, chemokines, and extracellular matrix components, including angiocrine factors or angiokines, involved in the regulation of organ morphogenesis, homeostasis, and regeneration. The concepts of angiocrine signaling have been demonstrated in the liver, pancreas, brain, lung, heart, kidney, skin, bone marrow, as well as in

The different local microenvironments in the kidney shape the molecular and metabolic heterogeneity of the renal endothelium; conversely, endothelial cell- derived angiocrine factors sustain the The vascular endothelium serves as a dynamic barrier that separates blood from interstitia. Endothelial cells (ECs) respond rapidly to changes in the circulation and actively regulate vessel tone, permeability, and platelet functions. ECs also secrete angiocrine factors that dictate the function of adjacent parenchymal cells in an organ-specific manner. Endothelial Substantial evidence has supported the role of endothelial cell (EC) activation and dysfunction in the development of hypertension, chronic kidney disease (CKD), and lupus nephritis (LN). In both humans and experimental models of hypertension, CKD, and LN, ECs become activated and release potent mediators of inflammation including cytokines,

Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms Article Dec 2022 Domenico Ribatti Giovanni Ligresti Roberto F. Nicosia

The endothelium first forms in the blood islands in the extra-embryonic yolk sac and then throughout the embryo to establish circulatory networks that further acquire organ-specific properties during development to support diverse organ functions. Here, we investigated the properties of endothelial cells (ECs), isolated from four human major organs—the heart, Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms. Ribatti D, Ligresti G, Nicosia RF Vascul Pharmacol, 148:107139, 17 Dec 2022 Cited by: 0 articles | PMID: 36539108 Review Claim to ORCIDGet citation The adult kidney is a highly vascularized organ characterized by a remarkable diversity of predominantly quiescent endothelial cell populations lining the blood and lymphatic vessels (Figure 1). The unique microenvironments within the kidney, delineated by distinct nephron segments, account for the extensive molecular and functional heterogeneity observed in the

1) Product Images from „Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms“ Article Title: Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms Journal: Vascular pharmacology doi: 10.1016/j.vph.2022.107139 During embryogenesis, endothelial cells participate in organogenesis before development of the fetal circulation, suggesting that endothelial cells are capable of releasing paracrine trophogens, named angiocrine factors, promoting morphogenesis and repair of the adjacent parenchyma/stroma where the vessels lie. Semaphorins in kidney development and disease: modulators of ureteric bud branching, vascular morphogenesis, and podocyte-endothelial crosstalk Pediatric Nephrology, 2011

1. Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms;Vascular Pharmacology;2023-02 2. Local angiogenic interplay of Vegfc/d and Vegfa drives brain region-specific development of fenestrated capillaries;2022-12-09 3. The vascular system originated around 600 million years ago. Endothelial cells evolved between 540 and 510 million years ago, and endothelial heterogeneity also developed. In invertebrates, two typologies have been described, the so-called open and closed systems, whereas in vertebrates only a closed system is present. In mammals, the presence of smooth Single-cell multiomic reconstruction of the human blood vessel organoid system allows for classifying and modeling disease and cell-type-specific states, demonstrating its potential for translational research.

The renal endothelium exhibits phenotypic and molecular traits that distinguish it from endothelia of other organs. Moreover, the adult kidney vasculature comprises diverse populations of mostly quiescent, but not metabolically inactive, endothelial cells (ECs) that reside within the kidney glomeruli, cortex and medulla. 3. Endothelial cell heterogeneity and differentiation;Auerbach,1992 4. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display;Rajotte;J. Clin. Invest.,1998 5. Endothelial cell diversity revealed by global expression profiling;Chi;Proc. Natl. Acad. Sci. U. S. A.,2003 全球学者库 1.学者识别 学者识别 Endothelial cells (ECs) undergo organ-specific specialization, driven by microenvironmental cues, to form patterned vascular networks. This article discusses mechanisms driving vascular inter

Review article Abstract only Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms D. Ribatti, G. Ligresti, R.F. Nicosia Vascular Pharmacology • Volume 148 • February 2023 View abstract

Article „Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms“ Detailed information of the J-GLOBAL is an information service managed by the Japan Science and Technology Agency (hereinafter referred to as „JST“). It provides free access to secondary information on researchers, articles, patents, etc., in science and technology,

The kidney is vascularized with highly specialized and zonated endothelial cells that are essential for its filtration function. Here, Barry et al. provide a single-cell RNA sequencing analysis of The pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell

Download Citation | On Apr 8, 2024, Sargis Sedrakyan published Kidney Endothelial Cell Biology in Health and Disease | Find, read and cite all the research you need on ResearchGate Request PDF | Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration | Microvascular endothelial cells (ECs) within different

Endothelial cells (ECs) that line vascular and lymphatic vessels are being increasingly recognized as important to organ function in health and disease. ECs participate not only in the trafficking of gases, metabolites, and cells between the bloodstream and tissues but also in the angiocrine-based induction of heterogeneous parenchymal cells, which are unique SUMMARY Adult organs are vascularized by specialized blood vessels. In addition to inter-organ vascular heterogeneity, each organ is arborized by structurally and functionally diversified populations of endothelial cells (ECs). The molecular pathways that are induced to orchestrate inter- and intra- organ vascular heterogeneity and zona-tion are shaped during development Signals from parenchymal cells provide cues to remodel the capillary network to meet the functional needs of the tissue and angiocrine factors released from ECs influence parenchymal cell survival, metabolic activity, and regenerative capacity.

The cells of the thick ascending limb and the distal tubule have abundant mitochondria and extensive infoldings of the basolateral membrane. The collecting duct is composed of two cell types: principal cells and intercalated cells. Principal cells have a moderately invaginated basolateral membrane and contain few mitochondria.

Purpose of Review Endothelial cells are of great importance in many types of diseases including the coronary artery diseases in heart and stroke in brain. In this review, we explore the heterogeneity among endothelial cells from an organism-wide, organ-specific, and healthy versus disease perspective. Recent Findings Recent studies addressing the cellular

Endothelial cells are now appreciated as a source of complex combinations of growth factors, known as Angiocrine factors, which direct tissue-specific microenvironments. Nolan et al. transcriptionally profiled microvascular endothelial cells from steady-state and regenerating tissues to create a database capable of identifying the characteristics of