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Biodegradable Polymer Nanogels For Drug/Nucleic Acid Delivery

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Many attempts have been made to develop biodegradable polymers for gene delivery by modifying existing polymers and/or using natural Abstract The present review focuses on the description of the design, synthesis and physico-chemical and biological evaluation of polymer nanogels. Nanogels are robust swollen cross-linked polymer nanoparticles that can be used as highly efficient and biodegradable carriers for the transport of drugs in controlled drug delivery.

Pharmaceutics | Free Full-Text | Biopolymer-Based Nanogel Approach in ...

Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic In the last few decades, there has been a growing interest in the use of biodegradable polymeric nanoparticles (BPNPs) as the carriers for various therapeutic agents in drug delivery systems. BPNPs have the potential to improve the efficacy of numerous active agents by facilitating targeted delivery to a desired site in the body. Biodegradable polymers In this review, new developments in the field of GSH-responsive nano-vehicles such as micelles, nanoparticles, capsules, polymersomes, nanogels, dendrimers, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs (e.g. doxorubicin and paclitaxel), photosensitizers, anti-oxidants, peptide and protein drugs

Nucleic acids-based nanosystems could be cataloged into hybrid DNA nanostructures and pure DNA nanostructures [24, 33, 34]. Hybrid DNA nanocarriers are typically constructed by decorating DNA onto a polymer that forms nanoscale framework through nucleobase pairing [35]. Biodegradable and biocompatible biomaterials have several important applications in drug delivery. The biomaterial family known as poly (ester amide)s (PEAs) has garnered considerable interest because it exhibits the benefits of both polyester and polyamide, as well as production from readily available raw ingredients and sophisticated synthesis techniques. Abstract With its nearly unrestricted possibilities, gene therapy attracts more and more significance in modern-day research. The only issue still seeming to hold back its clinical success is the actual effective delivery of genetic material. Nucleic acids are in general challenging to administer to their intracellular targets because of their unfavorable

Floxuridine-containing nucleic acid nanogels for anticancer drug delivery.

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBiodegradable Polymer Nanogels for Drug/Nucleic Acid DeliveryYulin Li*†‡, Dina Maciel†, João Rodrigues*†, Xiangyang Shi*†§, and Helena Tomás*†View Author Information† CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada 9000-390, Funchal, Portugal‡ The They can be used for the delivery of various drugs such as proteins/peptides, nucleic acids, and antitumor drugs. This chapter is aimed to provide recent updates on HA research, with an emphasis on the outstanding physicochemical properties of HA derivatives and their applications in drug delivery systems. The bioconjugation of nanogels with targeting elements yields highly selective multifunctional entities with potential for precision drug delivery applications. This review aims at providing a comprehensive summary of chemical synthesis methods for nanogel development for drug delivery applications.

Hydrogel with three-dimensional (3D) tunable porous structure are known as nanogels having particle size range of 1 to 100 nm and used as drug delivery carrier. Nanogels can be used to encapsulate small drug molecules, oligonucleotides, and proteins. Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.

This is our most recent contribution to the field published in Chemical Reviews. Enjoy it! Biodegradable Polymer Nanogels for Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. Requesting the following file: Biodegradable polymer nanogels for drug nucleic acid delivery.pdf

  • Polymeric nanogels as drug delivery systems
  • Polymers for Drug Delivery Systems
  • Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery.
  • Hyaluronic acid in drug delivery applications

Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery Chemical Reviews ( IF 51.4 ) Pub Date : 2015-08-11 12:07:25 , DOI: 10.1021/cr500131f Yulin Li 1, 2 , Dina Maciel 1 , João Rodrigues 1 , Xiangyang Shi 1, 3 , Helena Tomás 1 Gene therapy promises to treat diseases that arise from genetic abnormalities by correcting the underlying cause of the disease rather than treating the associated symptoms. Successful transfer of nucleic acids into cells requires efficient delivery vehicles that protect the cargo and can penetrate the appropriate cellular barriers before releasing their contents. Many ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTBiodegradable Polymer Nanogels for Drug/Nucleic Acid DeliveryYulin Li*†‡, Dina Maciel†, João Rodrigues*†, Xiangyang Shi*†§, and Helena Tomás*†View Author Information† CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada 9000-390, Funchal, Portugal‡ The

摘要： Recent advances on biodegradable polymer nanogels (NG) for the delivery of drugs/nucleic acids are reviewed. In combination with proper chemical modification, most biodegradable NGs are fabricated on the basis of natural polymers, which have good biocompatibility, biodegradability, and some of them biological signaling activity.

Hyaluronic acid in drug delivery applications

Many attempts have been made to develop biodegradable polymers for gene delivery by modifying existing polymers and/or using natural biodegradable Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability and difficulties in ensuring patient adherence. These challenges have driven the development of advanced drug delivery systems (DDS), with hydrogels and especially nanogels emerging as 已完结 文献求助详情 标题 Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery 相关领域 化学 基督教牧师 中国 引用 图书馆学 万维网 科学网 计算机科学 政治学 生物化学 梅德林 法学 网址 https://doi.org/10.1021/cr500131f DOI 10.1021/cr500131f 复制 doi 其它 期

In particular, the customized design and implementation of nontoxic, biocompatible, and biodegradable micro/nano carriers makes their usage very feasible for a range of biomedical applications, including drug delivery, tissue engineering, and bioimaging. The design and application methodologies of nanogels are outlined in this review. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery Yulin Li * , Dina Maciel , João Rodrigues * , Xiangyang Shi * , and Helena Tomás * Chemical Reviews 2015, 115, 16, 8564-8608 (Review) Publication Date (Web): August 11, 2015 First Page Full text PDF

  • Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
  • Chemical Reviews Vol. 115 No. 16
  • Biopolymer-Based Nanogel Approach in Drug Delivery: Basic
  • Recent progress of polymeric nanogels for gene delivery
  • Nanogels—Innovative Drug Carriers for Overcoming Biological

Nanoscopic vehicles that stably encapsulate drug molecules and release them in response to a specific trigger are of great interest due to implications in therapeutic applications, especially for cancer therapy. For this purpose, we have synthesized highly stable polymeric nanogels, in which the kinetics of guest molecule release can be fine-tuned by control over Thermoresponsive polymers have been investigated for a variety of clinical applications which make use of in situ gelation at physiological temperatures. However, for biomedical applications such as drug delivery and tissue engineering, thermoresponsive behavior and tunability must be balanced with biocompatibility and degradation kinetics. Significant Herein, we report the self-assemblies of floxuridine-containing DNA and RNA nanogels with a precise drug loading ratio as effective drug delivery systems. Based on the structural similarity between the nucleoside analogue floxuridine (F) and the natural nucleoside thymidine (T), F can be incorporated into nucleic acid strands via

Many delivery methodologies that prove effective in cell culture may be difficult to implement in vivo due to the biological membrane barriers exist in vivo[13], [14], [15]. Especially for the brain delivery, the nucleic acid-based drug must first cross the blood brain barrier (BBB), which is composed of endothelial cells of brain

The orthogonal functionalization of polymer chains with different chemical groups allows grafting of specific moieties and conjugating biomolecules to give rise to nanogels that are not only more attractive but also more efficient in drug and gene delivery, with the ability to avoid the activation of immune responses. 出版年份 2015 全文链接 首页 学术论文 论文搜索 论文详情 标题 Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery 作者 关键词 – 出版物

Nanogels as novel drug nanocarriers for CNS drug delivery

Therefore, it is crucial to summarize the existing preparation strategies, biological properties and recent applications of nucleic acid-based nanogels, which can help to seek new directions for the development of nanocarriers. This review summarizes various synthesis strategies and drug delivery mechanisms of nucleic acid-based nanogels. Polymer nanogels (NGs) are water-swellable, cross-linked 3D network structures with size typically range from 1 to 1000 nm. Especially, biocompatible and “smart” NGs engineered from stimuli-responsive polymers are attractive because of its capability to respond the endogenous biological triggers of pH, bioreduction, biomolecule recognition, as well as the A nanogel is a polymer -based, crosslinked hydrogel particle on the sub- micron scale. [1][2][3] These complex networks of polymers present a unique opportunity in the field of drug delivery at the intersection of nanoparticles and hydrogel synthesis. [1][2][3] Nanogels can be natural, synthetic, or a combination of the two and have a high degree of tunability in terms of their

Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, The orthogonal functionalization of polymer chains with different chemical groups allows grafting of specific moieties and conjugating biomolecules to give rise to nanogels that are not only more attractive but also more efficient in drug and gene delivery, with the ability to avoid the activation of immune responses.

Article „Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery“ Detailed information of the J-GLOBAL is an information service managed by the Japan Science and Technology Agency (hereinafter referred to as „JST“). It provides free access to secondary information on researchers, articles, patents, etc., in science and technology, medicine and pharmacy. The search results Biodegradable nanoparticles formulated from poly (d,l -lactide- co -glycolide) (PLGA) have been extensively investigated for sustained and targeted/localized delivery of different agents including plasmid DNA, proteins and peptides and low molecular weight compounds. Research about the mechanism of intracellular uptake of nanoparticles, their