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Asthma-Associated Genetic Variants Induce

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Recently, we generated a list of 128 independent single nucleotide polymorphisms (SNPs) associated with asthma in genome-wide association studies. However, it is unknown if Background Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset asthma (COA). However, the

A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes, glutathione S-transferases (GSTM1, GSTT1, GSTM3, GSTP1), manganese superoxide

Exploring TSLP and IL-33 Serum Levels and Genetic Variants

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Virtually all these genetic variants reside in non- coding genomic regions, which has obscured the functional impact of asthma- associated variants and their translation into disease- relevant

Introdution Genetic susceptibility and environmental exposure to children can influence their risk of developing asthma (Bouzigon et al. 2008, Lloyd and Saglani 2013). Daily

Abstract Background: In a genome-wide association study, genetic variants on chromosome 17q21 were strongly associated with childhood asthma and orosomucoid 1-like 3 (ORMDL3)

A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes, glutathione S-transferases (GSTM1, GSTT1, GSTM3, GSTP1), manganese superoxide

  • Asthma-associated genetic variants induce
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Yucesoy B, Johnson VJ, Lummus ZL, Kashon ML, Rao M, Bannerman-Thomp-son H, et al. Genetic variants in the major histocompatibility complex class I and class II genes are

Yucesoy B, Johnson VJ, Lummus ZL, Kashon ML, Rao M, Bannerman-Thomp-son H, et al. Genetic variants in the major histocompatibility complex class I and class II genes are Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma David I. Bernstein, MD, FAAAAI, Zana L. Lummus, PhD, Banu Kesavalu, MS,

The advent of new genotyping technologies has made it possible to sequence in great detail the human genome for asthma-associated variants, and accordingly, recent

  • Exploring TSLP and IL-33 Serum Levels and Genetic Variants
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  • Decoding the genetic and epigenetic basis of asthma
  • Genetic variants in antioxidant genes are associated with

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with asthma development in children, including several key regions (eg,

We hypothesized that regions localized to sites of RNAPII loading within eRNA-transcript signatures that change dynamically in response to anti-inflammatory glucocorticoids or pro Single nucleotide polymorphisms (SNPs) in TSLP are associated with asthma, yet studies have shown inconsistent associations between circulating TSLP and asthma. Studies Background: Genetic variants in the chromosomal region 17q21 are consistently associated with asthma. However, mechanistic studies have not yet linked any of the

Hidden Comorbidities in Asthma: A Perspective for a Personalized Approach

Objective The aim of this study was to investigate the influence of osthole (OS) on asthma-induced airway epithelial cell apoptosis and inflammation by restraining Th2 Sorry the service is unavailable at the moment. Please try again later.

Genetic Variants in Antioxidant Genes Are Associated With Diisocyanate-Induced Asthma May 2012 Toxicological Sciences 129 (1):166-73 DOI: 10.1093/toxsci/kfs183 Source Asthma is a syndrome with extremely diverse clinical phenotypes in which the onset, severity, and response to treatment are defined by the complex interplay of many

1. Introduction Asthma is a complex, heterogenous but one of the most common respiratory diseases that affects both children and adults worldwide, with diverse phenotypes and Our data demonstrate that asthma-associated variants at the IL33 locus mediate allele-specific regulatory activity and IL33 expression, providing a mechanism through which a regulatory

Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway Here, we provide an integrated overview of (epi)genetic variants associated with asthma, focusing on efforts to link these disease associations to biological insight into asthma pathophysiology

Asthma is a complex heterogeneous disease caused by gene–environment interactions. Although numerous genome-wide association studies have been conducted, Our data demonstrate that asthma-associated variants at the IL33 locus mediate allele-specific regulatory activity and IL33 expression, providing a novel mechanism through which a

Virtually all these genetic variants reside in non- coding genomic regions, which has obscured the functional impact of asthma- associated variants and their translation into disease- relevant Summary Hundreds of genetic associations for asthma have been identified, yet translating these findings into mechanistic insights remains challenging. We leveraged plasma

Objective: To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA). Methods: The study population consisted of 354

However, no other studies have demonstrated sporadic eosinophilia-associated genetic variants in this region. We previously reported the association of variations in candidate Susceptibility to asthma and severity of symptoms are regulated by a number of different genomic regions. Here the authors characterise a 5kb regulatory region and demonstrate genetic and

Asthma is common in the general population, including those in the workforce. 1,2 Work exposures can cause or exacerbate asthma 3 and can also be associated with asthma