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Article Types: Cell Metabolism

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Cell Metabolism Cell Press Sneak Peek is an author opt-in preview of the papers under review in our primary research journals. An invitation to submit to Sneak Peek is provided to all authors of primary research articles at the time they are first sent for peer review. Sneak Peek makes papers discoverable earlier in the publication process.

The types of redox modifications and the mechanism by which pro-apoptotic signals activate redoxins and consequently caspases appear cell-type-specific and context-specific 199.

Cell Metabolism | 新知识：乳酸分子直接结合并激活腺苷酸环化酶调控铁离子稳态 - 知乎

Acyl-CoA synthetase long-chain family 4 (ACSL4)-driven changes in lipid metabolism are shown to modulate the sensitivity of intestinal epithelial cells to ferroptosis, thereby exacerbating

Metabolic disorders: Types, causes, and symptoms

Considering that several metabolic pathways in B cells are involved differently, or even in opposite ways, in health and disease, we discuss how targeted modulation of B cell immunometabolism Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways Tatsuki Yasuda,1 Takaya Ishihara,1,2 Ayaka Ichimura,2 and Naotada Ishihara1,2,3,* Article on HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes., published in Cell metabolism on 2025-08-01 by Edgar Bernardo+21.

Sutton et al. conduct the first supervised controlled feeding trial to test whether intermittent fasting has benefits in humans in the absence of weight loss. Prediabetic men following a form of intermittent fasting called early time-restricted feeding improved their insulin sensitivity, blood pressure, and oxidative stress levels without losing weight. Metabolic reprogramming plays a pivotal role in cancer progression, contributing to substantial intratumour heterogeneity and influencing tumour behaviour. However, a systematic characterization of metabolic heterogeneity across multiple cancer types at the single-cell level remains limited.

This theory brings together biophysics and cell biology in a tractable model that can be applied to understand key principles of cell metabolism. Metabolism, the sum of chemical reactions that take place in living cells, providing energy for life processes and the synthesis of cellular material. Living organisms are unique in that they extract energy from their environments via hundreds of coordinated, multistep, enzyme-mediated reactions. At this year’s ASCB Minisyposium, 10 speakers discussed how cellular metabolism contributes to different cellular functions. Although we know most of the components of cellular metabolic pathways, our understanding on how these pathways are rewired in different environmental and disease contexts has been limited.

Similar content being viewed by others Cellular metabolism regulates the differentiation and function of T-cell subsets Article Open access 02 April 2024 Summary Type 2 diabetes (T2D) is a devastating chronic disease marked by pancreatic β cell dysfunction and insulin resistance, whose pathophysiology remains poorly understood. HNF1A, which encodes transcription factor hepatocyte nuclear factor-1 alpha, is the most commonly mutated gene in Mendelian diabetes.

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. Dai et al. examined electrical and transcriptomic α cell phenotypes and found that dysfunction in type 2 diabetes is linked to cell maturation state and impaired α cell identity. Notably, a subset of α cells enriched for lineage markers appears uniquely susceptible to dysfunction. In this issue of Nature Metabolism, Li et al. reveal that disruptions in mitochondrial protein folding are an early trigger of β-cell dysfunction in type 2 diabetes and highlight that LONP1 has a

Skeletal muscles show high metabolic flexibility and functional plasticity in their response to different exercise modalities. Recent findings have advanced our understanding of signalling

A physical model of cell metabolism

Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses uncovered impaired glucose sensing, suggesting a parallel pathway of beta cell metabolic dysfunction that contributes to type 1 diabetes pathogenesis. Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the combination of genetic and environmental factors, and obesity, lifestyle, and aging are the most relevant risk factors. Hyperglycemia is the main metabolic feature of T2D as a consequence of insulin resistance and β-cell dysfunction. Emerging evidence has implicated WNT signaling in the regu-lation of cellular metabolism. A missense mutation in LRP6 has been linked with abnormal whole-body metabolism in humans (Mani et al., 2007). Genomic polymorphism of TCF7L2, a tran-scriptional effector of WNT/b-catenin signaling, is associated with type II diabetes (Grant et al., 2006).

Hall et al. investigated 20 inpatient adults who were exposed to ultra-processed versus unprocessed diets for 14 days each, in random order. The ultra-processed diet caused increased ad libitum energy intake and weight gain despite being matched to the unprocessed diet for presented calories, sugar, fat, sodium, fiber, and macronutrients.

In cells with mitochondrial oxidative phosphorylation defects, galactose metabolism through glycolysis is too slow to generate enough ATP to meet metabolic demands, resulting in metabolic catastrophe and cell death. Furthermore, metabolism is a key player in mediating quiescence–proliferation transitions in physiologically important cell types, such as stem cells. How metabolism impacts cell cycle progression, exit, and re-entry, as well as how these processes impact metabolism, is not fully understood.

There is growing appreciation that the metabolism of cell types other than cancer cells within the TME, including endothelial cells, fibroblasts and immune cells, can modulate tumour progression.

Introduction Cellular metabolism comprises the controlled biochemical processes that occur within a cell to maintain life. It is generally divided in, anabolic processes (the build-up of macromolecules) and catabolic processes (the breakdown of macromolecules). To maintain constant cellular conditions in response to changes in the environment (homeostasis) a cell Integrative single-cell metabolomics and phenotypic profiling reveals metabolic heterogeneity of cellular oxidation and senescence Ziyi Wang, Siyuan Ge, Tiepeng Liao, Man Yuan, Wenwei Qian, Qi Chen,

McGaha and colleagues review recent research on the metabolic programs of tumor-associated macrophages across cancer types and discuss their implications on potential therapeutic vulnerabilities. In humans, cell metabolism is integrated into a complex biological network that involves a wide range of metabolites and ubiquitous metabolite-sensing mechanisms. Type 2 diabetes (T2D) is a complex metabolic disorder characterized by gene-environment factors contributing to pancreatic islet β

Review Article Published: March 2008 Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes Deborah M. Muoio & Christopher B. Newgard Nature Reviews

The liver is composed of several cell types of different embryological origin including hepatocytes, biliary epithelial cells (cholangiocytes), stellate cells, Kupffer cells, and liver sinusoidal endothelial cells. Each of these cell types possesses unique functions that cooperatively regulate hepatic function at multiple levels.

This method allows mapping of cell-type-specific dynamic changes in central carbon metabolism in the context of a complex heterogeneous tissue architecture, such as the kidney. Cell Press is committed to meeting the growing demand for open access and new publishing model options. Explore your open access options with Cell Press. In multicellular organisms, metabolism is compartmentalized at many levels, including tissues and organs, different cell types, and subcellular

Cellular metabolism is rewired in proliferating cells to support their increased need for macromolecule biosynthesis. A better understanding of how cells utilize nutrients for biosynthetic What is metabolism? Metabolism is how your body turns food and drink into energy to keep you alive and functioning. It’s made up of all the chemical processes happening in your body’s cells every second. These processes help you breathe, move, heal and more. Keeping these processes balanced is called homeostasis. It’s what keeps your body running smoothly.