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A Nanotherapeutic Strategy To Overcome Chemotherapeutic

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Meacham, C. E. & Morrison, S. J. Tumour heterogeneity and cancer cell plasticity. Nature 501, 328–337 (2013). 3. Nanomaterials-based therapeutics for cancer stem cells The significance of CSCs in cancer therapy cannot be overstated, making it imperative to develop precise 3.5. Nanotechnology-Based Strategies to Overcome Multidrug Resistance Although the discovery of multiple ABC inhibitors holds promise for the treatment of MDR, these modulators face

Schematic of various mechanisms by which nanoconstructs overcome MDR ...

In a recent nanotherapeutic strategy, nanoparticles co-loaded with chemotherapeutic drug, camptothecin, and differentiation-inducing agent, all-trans retinoic acid, A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells Shiyang Shen, Xiao Xu, Shiqi Lin, Ying Zhang, Huayu Liu, Can Zhang and Ran Mo Tumour

Tumour heterogeneity remains a major challenge in cancer therapy owing to the different susceptibility of cells to chemotherapy within a solid tumour. Cancer stem-like cells (CSCs), Albumin-based nanocarriers to overcome cancer drug resistance for various types of tumors Albumin nanocarriers have been prepared, serving as drug delivery systems, to overcome

利用纳米载体克服肿瘤异质性障碍_干细胞

Highlights • Comprehensive overview of CSC biology is systematically summarized. • Recent advancements of nanotherapeutic strategies exploiting the biological traits of CSC are

Cancer stem cells (CSCs) represent a distinct subpopulation of cancer cells that orchestrate cancer initiation, progression, metastasis, and therapeutic resistance. Despite 3. Shiyang Shen; Xiao Xu; Shiqi Lin; Ying Zhang; Huayu Liu; Can Zhang; Ran Mo*. A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells. The perivascular niche regulates breast tumor dormancy Normalizing the microenvironment overcomes vessel compression and resistance to Nano-immunotherapy in

Cancer nanotherapeutics were created in order to overcome the inherent limitations of traditional chemotherapeutics. Over the last few decades, cancer The combined application of multiple drugs (e.g., chemotherapeutic drug, siRNA) targeting different cellular signal pathways can raise the genetic barriers for cancer cell mutations [72 –

  • 中科中山药物创新研究院
  • Phytic acid-modified CeO2 as Ca2+ inhibitor for a security
  • The p38/MAPK pathway as a therapeutic target to prevent
  • 沈诗洋—-中国科学院上海药物研究所

Insight of nanomedicine strategies for a targeted delivery of nanotherapeutic cues to cope with the resistant types of cancer stem cells Reprinted with permission from „A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells,“ by Shen S, Xu X, Lin S, Zhang Y, Liu H, Zhang C, et al. Combination chemotherapy is a crucial therapeutic strategy to improve the therapeutic efficacy of breast cancer in clinic. When combined with photodynamic therapy

One example is the combination of both approaches we describe here to (1) engineer a chemotherapeutic regimen that focally releases anticancer cytotoxic drugs followed by (2) a A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stemlike cells. Nat Nanotechnol 16, 104–113. Article PubMed CAS Google Scholar Shrestha,

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells Publisher preview available Article Jan 2021

Multiple treatment strategies have been proposed to overcome this resistance to treatment, interfering both in the factors mentioned above and in other related mechanisms. 莫然，博士、教授、博士生导师，生命科学与技术学院副院长，国家万人计划青年拔尖人才、江苏省杰出青年基金获得者、江苏省双创人才、江苏特聘教授。兼任中国药学会药剂专业委员会青 Crossref View in Scopus Google Scholar [6] S. Shen, X. Xu, S. Lin, Y. Zhang, H. Liu, C. Zhang, R. Mo A nanotherapeutic strategy to overcome chemotherapeutic resistance of

2021年1月12日， 中国药科大学天然药物活性组分与药效国家重点实验室 莫然团队在 Nature Nanotechnology 上发表题为： A nanotherapeutic strategy to overcome A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells Article Full-text available Jan 2021

2021年1月12日，中国药科大学天然药物活性组分与药效国家重点实验室莫然团队在 Nature Nanotechnology 上发表题为：A nanotherapeutic strategy to overcome chemotherapeutic However, resistance phenotype in cancer cells leads to unsatisfactory results in the efficiency of therapeutic strategies. Therefore, researchers strive to propose effective In recent years, emerging evidence demonstrated that some nanomaterials have distinct advantages in reducing side effects and overcoming drug resistance. The following will

However, CDT and CDT-combined strategies circumvent the reliance on drug efflux pumps, thereby enabling the potential to overcome multidrug resistance. Furthermore,

Cancer remains a leading cause of death worldwide, necessitating the development of innovative and more effective treatment strategies. Conventional cancer In a recent nanotherapeutic strategy, nanoparticles co-loaded with chemotherapeutic drug, camptothecin, and differentiation-inducing agent, all-trans retinoic acid, demonstrated CSCs This review focuses on advances in nanomedicine-mediated therapeutic strategies to overcome chemoresistance by specifically targeting CSCs, the combination of chemotherapeutics with

Multiple treatment strategies have been proposed to overcome this resistance to treatment, interfering both in the factors mentioned above and in other related mechanisms.

Tumour heterogeneity remains a major challenge in cancer therapy owing to the different susceptibility of cells to chemotherapy within a solid tumour. Cancer stem-like cells (CSCs),

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells Tumour heterogeneity remains a major challenge in cancer therapy owing to the different A nanotherapeutic strategy is developed using tumor-penetrating peptide iRGD-modified high-density lipoprotein (HDL)-mimetic nanodiscs (IPCND) that ingeniously loaded with

2021年1月12日， 中国药科大学天然药物活性组分与药效国家重点实验室 莫然团队在 Nature Nanotechnology 上发表题为： A nanotherapeutic strategy to overcome chemotherapeutic Sci-Hub | A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells. Nature Nanotechnology, 16 (1), 104–113 | 10.1038/s41565-020-00793-0

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells Shiyang Shen, Xiao Xu, Shiqi Lin, Ying Zhang, Huayu Liu, Can Zhang and Ran Mo Tumour